Innovative tools

for structural

biology

Innovative tools

for structural biology

about us

We provide solutions for

Structural Biology

Structural Biology

Macromolecular crystallography suffers from two major issues: getting well-diffracting crystals and solving the phase problem inherent to large...

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Obtaining Crystals

Obtaining Crystals

Thanks to versatile binding sites and supramolecular interactions, POLYVALAN Xo4 products provide new crystallization conditions and also improves...

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Phase problem

Phase problem

POLYVALAN Xo4 are straightforward phasing agents overcoming the tedious and time-consuming work of existing solutions: seleno-methionine labelling...

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POLYVALAN competitive edge is its unique chemical approach allowing significant gain of effectiveness, time and/or precision for protein structure determination that allows an optimal use of the existing large equipments.

ABOUT US
What we do

New efficient products for the protein crystallographer’s toolbox

Organic & Coordination Chemistry
Biophysics
Structural Biology
Polyvalan skills

More than 20 years of team experience in solving the phase problem

NUCLEATING AGENT

Xo4 products – Promote crystal growth and reproducibility – Improve hit rate – Enhance crystal quality – and Induce new crystal forms

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PHASING AGENT

Xo4 products are straightforward phasing agents overcoming the tedious and time-consuming work of existing solutions like seleno-methionine labelling…

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ACHIEVEMENTS

With Xo4

6RQA Crystal structure of the iminosuccinate reductase of Paracoccus denitrificans in complex with NAD+

6QSS Crystal Structure of Ignicoccus islandicus malate dehydrogenase co-crystallized with 10 mM Tb-Xo4.

6Q3T Structure of Protease1 from Pyrococcus horikoshii at room temperature in ChipX microfluidic device.

6HK1 Crystal structure of the Thiazole synthase from Methanothermococcus thermolithotrophicus co-crystallized with Tb-Xo4.

Images from the RCSB PDB (rcsb.org)

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meet the team

We develop a full range of complementary products

Christian Chapelle
Christian Chapelle
CEO
POLYVALAN unique chemical approach provides significant gain of effectiveness, time and/or precision for protein structure determination that...
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Xo4 trial will take place at the HTX platform over June and July 2021. Choose your screening plates and request a booking with the Xo4-standard crystallization setup. See details here: linkedin.com/feed/update/ur…

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