Innovative tools

for structural

biology

Innovative tools

for structural biology

about us

We provide solutions for

Structural Biology

Structural Biology

Macromolecular crystallography suffers from two major issues: getting well-diffracting crystals and solving the phase problem inherent to large...

Learn more
Obtaining Crystals

Obtaining Crystals

Thanks to versatile binding sites and supramolecular interactions, POLYVALAN Xo4 products provide new crystallization conditions and also improves...

Learn more
Phase problem

Phase problem

POLYVALAN Xo4 are straightforward phasing agents overcoming the tedious and time-consuming work of existing solutions: seleno-methionine labelling...

Learn more

POLYVALAN competitive edge is its unique chemical approach allowing significant gain of effectiveness, time and/or precision for protein structure determination that allows an optimal use of the existing large equipments.

ABOUT US
What we do

New efficient products for the protein crystallographer’s toolbox

Organic & Coordination Chemistry
Biophysics
Structural Biology
Polyvalan skills

More than 20 years of team experience in solving the phase problem

NUCLEATING AGENT

Xo4 products – Promote crystal growth and reproducibility – Improve hit rate – Enhance crystal quality – and Induce new crystal forms

LEARN MORE

PHASING AGENT

Xo4 products are straightforward phasing agents overcoming the tedious and time-consuming work of existing solutions like seleno-methionine labelling…

LEARN MORE
ACHIEVEMENTS

With Xo4

6RQA Crystal structure of the iminosuccinate reductase of Paracoccus denitrificans in complex with NAD+

6QSS Crystal Structure of Ignicoccus islandicus malate dehydrogenase co-crystallized with 10 mM Tb-Xo4.

6Q3T Structure of Protease1 from Pyrococcus horikoshii at room temperature in ChipX microfluidic device.

6HK1 Crystal structure of the Thiazole synthase from Methanothermococcus thermolithotrophicus co-crystallized with Tb-Xo4.

Images from the RCSB PDB (rcsb.org)

0
Products available
0
Citations
0
Achievements
meet the team

We develop a full range of complementary products

Christian Chapelle
Christian Chapelle
CEO
POLYVALAN unique chemical approach provides significant gain of effectiveness, time and/or precision for protein structure determination that...
SEE MORE

Latest paper related to Tb-Xo4 and Lu-Xo4. The principle of a database aimed at facilitating the understanding of the unique protein nucleating properties of the Crystallophore is presented in. crystallophore.fr/publication…

Il y a 2 mois De Polyvalan - Crystallophore's Twitter via Twitter Web App