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BacA: a possible regulator that contributes to the biofilm formation of Pseudomonas aeruginosa Front. Microbiol., 05 March 2024 Sec. Microbial Physiology and Metabolism Volume 15 – 2024 https://doi.org/10.3389/fmicb.2024.1332448

Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations. Commun Biol 7, 111 (2024). https://doi.org/10.1038/s42003-023-05726-w


Solution X-ray scattering highlights discrepancies in Plasmodium multi-aminoacyl-tRNA synthetase complexes Protein Science Volume32, Issue2 February 2023 e4564 https://doi.org/10.1002/pro.4564

A Cold-Active Flavin-Dependent Monooxygenase from Janthinobacterium svalbardensis Unlocks Applications of Baeyer–Villiger Monooxygenases at Low Temperature ACS Catal. 2023, 13, 6, 3549–3562 Publication Date:February 27, 2023  https://doi.org/10.1021/acscatal.2c05160

Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery Molecular Biology and Evolution, Volume 40, Issue 10, October 2023, msad223, https://doi.org/10.1093/molbev/msad223


Crystal structure of DNA polymerase I from Thermus phage G20c – Acta Cryst. (2022). D78, 1384-1398 https://doi.org/10.1107/S2059798322009895

New structural insights into the PI -2 pilus from Streptococcus oralis, an early dental plaque colonizer – FEBS Journal (2022), 289(20), 6342-6366 https://doi.org/10.1111/febs.16527

Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy – Nat Commun (2022) 13: 4446-4446 https://doi.org/10.1038/s41467-022-32215-1


An automated platform for structural analysis of membrane proteins through serial crystallography – Cell Reports Methods, Volume 1, Issue 6, 100102 – October 2021 https://doi.org/10.1101/2021.06.03.446146

Biochemical, structural and dynamical studies reveal strong differences in the thermal-dependent allosteric behavior of two extremophilic lactate dehydrogenases – Journal of Structural Biology, 213(3), 107769 – July 2021 https://doi.org/10.1016/j.jsb.2021.107769

Capturing the dynamic association between a tris-dipicolinate lanthanide complex and a decapeptide: a combined paramagnetic NMR and molecular dynamics exploration – Physical Chemistry Chemical Physics, 23(19), 11224-11232 – May 2021 https://doi.org/10.1039/d0cp06570f

Lanthanide-Protein Interactions and their Use in Determination of Protein Structure, Function, and Dynamics -Analytical Chemistry Letters, 11(3), 315-342 – May 2021https://doi.org/10.1080/22297928.2021.1890638



Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol Lu Zhang, Yao Zhao, Yan Gao, Lijie Wu, Ruogu Gao, Qi Zhang, Yinan Wang, Chengyao Wu, Fangyu Wu, Sudagar S. Gurcha, Natacha Veerapen, Sarah M. Batt, Wei Zhao, Ling Qin, Xiuna Yang, Manfu Wang, Yan Zhu, Bing Zhang, Lijun Bi, Xian’en Zhang, Haitao Yang, Luke W. Guddat, Wenqing Xu, Quan Wang, Jun Li, Gurdyal S. Besra, Zihe Rao (2020) – Science  23 Apr 2020: eaba9102 DOI: 10.1126/science.aba9102

Crystal structure of Mokola virus glycoprotein in its post-fusion conformation Belot L, Ouldali M, Roche S, Legrand P, Gaudin Y, et al. (2020) – PLOS Pathogens 16(3): e1008383. https://doi.org/10.1371/journal.ppat.1008383

The C‐terminal domain of Corynebacterium glutamicum mycoloyltransferase A is composed of five repeated motifs involved in cell wall binding and stability C Dietrich, I Li de la Sierra‐Gallay, M Masi, E Girard, N Dautin, F Constantinesco‐Becker, M Tropis, M Daffé, H van Tilbeurgh, N Bayan – Molecular Microbiology, published February 2020 https://doi.org/10.1107/s2053230x1901642x

The adhesive PitA pilus protein from the early dental plaque colonizer Streptococcus oralis: expression, purification, crystallization and X-ray diffraction analysis Rajnesh Kumari Yadav, Vengadesan Krishnan – Acta Crystallographica Section F: Structural Biology Communications, 76(Pt 1), 8-13, January 2020 https://doi.org/10.1107/s2053230x1901642x


Molecular insight into a new low‐affinity xylan binding module from the xylanolytic gut symbiont Roseburia intestinalis Maria Louise Leth, Morten Ejby, Eva Madland, Yoshihito Kitaoku, Dirk J. Slotboom, Albert Guskov, Finn Lillelund Aachmann, Maher Abou Hachem – The FEBS Journal, November 2019 https://doi.org/10.1111/febs.15117

Crystal structures of the Bacillus subtilis prophage lytic cassette proteins XepA and YomS Stefanie Freitag-Pohl, Andrius Jasilionis, Maria Håkansson, L. Anders Svensson, Rebeka Kovačič, Martin Welin, Hildegard Watzlawick, Lei Wang, Josef Altenbuchner, Magdalena Płotka, Anna Karina Kaczorowska, Tadeusz Kaczorowski, Eva Nordberg Karlsson, Salam Al-Karadaghi, Björn Walse, Arnthór Aevarsson, Ehmke Pohl – Acta Crystallographica Section D, Structural Biology, 75(11), 1028-1039, November 2019 https://doi.org/10.1107/s2059798319013330

Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle Lennart Schada von Borzyskowski, Francesca Severi, Karen Krüger, Lucas Hermann, Alexandre Gilardet, Felix Sippel, Bianca Pommerenke, Peter Claus, Niña Socorro Cortina, Timo Glatter, Stefan Zauner, Jan Zarzycki, Bernhard M. Fuchs, Erhard Bremer, Uwe G. Maier, Rudolf I. Amann, Tobias J. Erb – Nature, 575(7783), 500-504, November 2019 https://doi.org/10.1038/s41586-019-1748-4

The archaeal LDH-like malate dehydrogenase from Ignicoccus islandicus displays dual substrate recognition, hidden allostery and a non-canonical tetrameric oligomeric organization Jennifer Roche, Eric Girard, Caroline Mas, Dominique Madern – Journal of Structural Biology, 208(1), 7-17, October 2019 https://doi.org/10.1016/j.jsb.2019.07.006

A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallographe Raphaël de Wijn, Oliver Hennig, Jennifer Roche, Sylvain Engilberge, Kevin Rollet, Pablo Fernandez-Millan, Karl Brillet, Heike Betat, Mario Mörl, Alain Roussel, Eric Girard, Christoph Mueller-Dieckmann, Gavin C. Fox, Vincent Olieric, José A. Gavira, Bernard Lorber, Claude Sauter – IUCrJ, 6(Pt 3), 454-464, May 2019 https://doi.org/10.1107/s2052252519003622


They talk about Xo4


Various additives were tested to improve crystal quality and size.  The best results were achieved with the recently described nucleating and phasing agent Tb-Xo4.

Nature  575, 500–504 (2019).

Schada von Borzyskowski & al.Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle.


Beauty is in the eye of the beholder! - These sorta ugly Tb (Xo4) co-crystals enabled us to solve a tricky phase problem (originally P1 space group, indifferent resolution, yada yada) which has been plaguing us for almost 5 years

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