Innovative tools
for structural
biology
Innovative tools
for structural biology
about us
We provide solutions for
Structural Biology
Macromolecular crystallography suffers from two major issues: getting well-diffracting crystals and solving the phase problem inherent to large...
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Obtaining Crystals
Thanks to versatile binding sites and supramolecular interactions, POLYVALAN Xo4 products provide new crystallization conditions and also improves...
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Phase problem
POLYVALAN Xo4 are straightforward phasing agents overcoming the tedious and time-consuming work of existing solutions: seleno-methionine labelling...
Learn moreABOUT USPOLYVALAN competitive edge is its unique chemical approach allowing significant gain of effectiveness, time and/or precision for protein structure determination that allows an optimal use of the existing large equipments.
What we do
New efficient products for the protein crystallographer’s toolbox
Polyvalan skills
More than 20 years of team experience in solving the phase problem
NUCLEATING AGENT
Xo4 products – Promote crystal growth and reproducibility – Improve hit rate – Enhance crystal quality – and Induce new crystal forms
PHASING AGENT
Xo4 products are straightforward phasing agents overcoming the tedious and time-consuming work of existing solutions like seleno-methionine labelling…
ACHIEVEMENTS
With Xo4
6RQA Crystal structure of the iminosuccinate reductase of Paracoccus denitrificans in complex with NAD+
6QSS Crystal Structure of Ignicoccus islandicus malate dehydrogenase co-crystallized with 10 mM Tb-Xo4.
6Q3T Structure of Protease1 from Pyrococcus horikoshii at room temperature in ChipX microfluidic device.
6HK1 Crystal structure of the Thiazole synthase from Methanothermococcus thermolithotrophicus co-crystallized with Tb-Xo4.
meet the team
We develop a full range of complementary products
Christian Chapelle
Xo4 trial will take place at the HTX platform over June and July 2021. Choose your screening plates and request a booking with the Xo4-standard crystallization setup. See details here: linkedin.com/feed/update/ur…